Prof. Dr. Atta-ur-Rahman E-mail: atta.rahman@iccs.edu |
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Prof. Dr. M. Iqbal Choudhary H.I.,S.I.,T.I. E-mail: iqbal.choudhary@iccs.edu |
Over 550 research publications in top international journals with cumulative impact factor of 900 and 2700 citations, ten national and international patents and ten books published and circulated internationally. He is holding a visiting professor position at King Saud University. He is also the Editor-in-Chief of two European science journals. His current research interests include search for new and effective enzyme inhibitors, anti-oxidant agents and anti-parasitic compounds.
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Prof. Dr. Muhammad Anwar Waqar S.I.,T.I. E-mail:anwar_waqar@hotmail.com |
Over 170 research publications in international journals of repute. He is a member of editorial boards of various scientific journals and promotion committees of international universities. His current research interests include role of urinary modulators in urolithiasis, evaluation of herbal preparations for kidney stones, allergies, asthma and inhalant allergens and determination of the molecular mechanism of herbal and determination of the molecular mechanisms of action of herbal drugs in Type 2 Diabetes mellitus.
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Prof. Dr. Ahsana Dar E-mail:ahsana.dar@iccs.edu; |
Over 30 research publications. Her research interests include evaluation of synthetic compounds, natural products (marine/terrestrial) and herbal preparations for depression and other neurological disorders, cancer, analgesic and inflammation. A variety of in vitro and in vivo assays and HPLC techniques etc. are employed to assess the aforementioned activities and elucidate their mechanism of action. Pharmacological effects of drugs used in depressed and schizophrenic patients along with their neurotransmitter and enzyme levels are under progress. Prof. Dar is also an International Research Coordinator.
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Prof. Dr. Nurul Kabir E-mail:nkabir1@hotmail.com; |
Over 10 research publications in top-quality international journals. Research interests include cell biology observed by high-resolution light microscopy in diverse fields such as neurobiology, liver toxicity, embryology and immunology; exploring novel natural products for treatment of Parkinsonism or Paracetamol-induced liver injury by using differential interference contrast (DIC), multi-channel fluorescence and deconvolution microscopy.
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Prof. Dr. Kaneez Fatima Shad E-mail: ftmshad@yahoo.com |
Dr. Shad has 89 Publications (including 17 full refereed papers in international journals, 10 invited reviews and 62 presentations) in international conferences. She is also a conjoint professor of UAE University, UAE and University of New South Wales, Sydney, Australia. Recently she has been appointed for three years as Visiting Professor at the University of Technology Sydney. She is also Adjunct professor of University of Health Sciences Lahore and Dow University of Health Sciences Karachi. She is interested in investigating “Biological Markers for Metabolic Mental Disorders” using techniques and protocols of electrophysiology (e.g. patch clamping), mutagenesis coupled with single cell RT-PCR and biochemistry. She is alsoworking on the "Protective Effect of SFE extracted Nigella sativa extract on petrochemical pollutant induced oxidative stress in vivo and in vitro" and “Diabetes associated altered cardiac function". Recently she has received Rs 2.569 million University grant from HEC for the project of “DNA receptor and neurogenin studies in Schizophrenic patients from Pakistan”.
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Dr. Muhammad Kamran Azim E-mail:kamran.azim@iccs.edu |
12 Research publications in area of Proteolytic Enzymology. Recipient of prestigious Alexander von Humboldt fellowship (Germany). Research interests include Structural Biology and Bioinformatics of proteases and their regulatory components with especial reference of the Proteosome and the intracellular protein degrading machinery.
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Dr. Shabana U. Simjee E-mail:sh01us@hotamil.com |
Primary research focus is on issues related to chronic pain and chronic illness and the effects of persistent pain on brain neurotransmitter systems; Neuropharmacology of chronic pain; exploring how neuropeptides and growth factors are involved in regulating inflammation and the immune and wound healing response.
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Dr. Zaheer-ul-Haq Qasmi E-mail:zaheer.qasmi@iccs.edu |
30 research publications. He is a Computational Medicinal Chemist. His research interest includes design of new bio-active molecules using computer aided modeling techniques, modeling of small organic molecules, proteins, and protein-ligand interactions, ligand based and structure based pharmacophore design, generation and screening of large virtual combinatorial compound libraries, molecular activity determination using 3D-QSAR or quantum chemistry calculations, and Molecular Dynamics (MD) simulations studies of protein-ligand complex. Personal Webpage: Area of Research:
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Dr. Muhammad Ahmed Mesaik E-mail:mmesaik@hotmail.com |
17 research publications. His main research work includes immuno-modulatory activity of natural compounds analyzing immune responses (stimulatory / inhibitory). Research interests include exploring how compounds suppress inflammatory cytokines involved in rheumatoid arthritis e.g. IL-1, TNF-γ by down regulating their production. He also manages immuno-modulatory and cytotoxicity bioassay screening activities besides the study of T and B cell response in relation to transplantation and graft rejection.
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Dr. Asmat Salim E-mail:salimasmat@yahoo.com |
13 research publications. She is currently involved in the study of differentiation mechanisms of bone marrow derived stem cells into cardiac micro-environment both in vitro and in vivo. This includes stem cell isolation, propagation, identification and transplantation into theinfarcted heart and determination of their fate by functional analysis. The in vitro analysis includes studies related to fusion of different cell types in culture and analysis of the fused cells by identification of surface markers they express.
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Dr. Huma Rasheed
E-mail: huma.rasheed@iccs.edu |
24 research publications. Her research program deals with cancer genomics and therapeutics that relates with the identification of the genetic mechanism responsible for multi-drug resistance as a result of cancer chemotherapy. The functions of various onco- and tumor suppressor genes can be disrupted at different stages of tumor progression. The aim is to investigate the molecular mechanism of specific drugs and endogenous mediators that directly target oncogenes and arrest cell proliferation, tumor progression or oncogenesis by acting on angiogenesis, cell signaling/regulation pathways and genetic programs initiated by damaged DNA. The study is also based on the expression of novel tumor suppresser genes and identification of prognostic markers for use in the management of cancer.
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Dr. Talat Makhmoor
Email: makhmoor@iccs.edu |
7 research publications. Her current research involves analysis of peptide antigen loading on the cells expressing Major Histocompatibilty Complexes (MHC) in the presence of catalytic amount of small organic compounds thus studying the cellular mechanisms involved in autoimmune reactions. Effective compounds can therefore be used as molecular tools in therapeutic settings. Research work also includes evaluation of anti-oxidant properties of organic compounds.
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Dr. Muhammad Hafizur Rahman E-mail:hafizpcmd@yahoo.com |
7 research publications. His current research projects involve developing of streptozotocin-induced animal models of diabetes and investigating the effects of natural products in model diabetic rats. A variety of in vitro and in vivo assays are employed to elucidate the mechanism of action of anti-diabetic plant extracts. The study deals with the histological/ immunohistochemical change(s) of the pancreatic islets that occur in diabetic rats and whether these changes can be prevented by different natural products. Further in depth studies are focused on direct immunohistochemical evidence of pancreatic beta-cell regeneration in model diabetic rats treated with known anti-diabetic plant extracts.
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Dr.Sonia Siddiqui E-mail:Siddisbs@yahoo.com |
Dr. Siddiqui has 7 publications including 3 in peer-reviewed journals. Her research interest included, the role of extracellular matrix proteins (especially Tenascin-C and Chondroitin Sulphate Proteoglycans) on retinal neurite outgrowth during embryonic and postnatal stages. She is also interested in identifying the role of neuron glia interactions during ontogencity.. Currently she is working as Research officer her responsibilities at present are co supervising BioBank, learning patch clamp techniques at PCMD, University of Karachi. Area (s) of interest
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Ms. Samreen Falak Research Officer |
Current research studies involve analyses of complex cardiovascular diseases using rat as a model system. Main focus is directed towards the identification of underlying predisposing genes, subsequent identification of their molecular variants and establishing multiple congenic rat strains and molecular analysis. Research work also includes a combinatorial approach of positional cloning and expression profiling which serve as a powerful tool to identify positional candidate genes within chromosomal regions for genetically determined cardiovascular diseases.
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Mr. Muhammad Waqar Hameed |
Current research includes investigation of transcriptional and translational regulation of the expression of mitochondrial genes using microarrays. Genetic modification of genes encoding mitochondrial proteins include the cloning and subsequent over expression or silencing of genes of interest. Future investigations include measuring of ribosomal activity by polysome analysis and the effect of transgenic approaches on the mitochondrial energy production mechanism.
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Hareem Ilyas E-mail:hareem.ilyas@gmail.com |
Hareem Ilyas holds a Master’s of Science (MSc.) degree in Molecular Biology, from Canada, during which she has 1 peer-reviewed publication. Her MSc. was fully funded with a scholarship from the Heart and Stroke Foundation of Canada. Her BSc. in Biology was with a Specialized Honors in Biotechnology. Furthermore, her diploma in Pharmaceutical Chemical Laboratory Technology yielded an Academic Achievement Award from the Canadian Institute of Chemistry. She spent three years in a muscle development research lab in Canada where the focus of her research was the development of a new tool for molecular biology to aid controlling gene expression in mammalian cell culture systems. In addition to being skilled in cell culture techniques, she is also well versed with recombinant DNA technology such as cDNA cloning and recombinant protein expression.
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Dr. Rafat Ali Siddiqui
E-mail:rsiddiqu@clarian.org |
The focus of Cellular Biochemistry Laboratory is to investigate the cellular and molecular mechanisms through which nutrients affect human health. We are particularly investigating how fatty acids influence the development and progression of cardiovascular diseases and cancer. Our cellular and animal models have shown that trans-fatty acids (found in hydrogenated oils) instigate molecular processes that induce atherosclerosis and sudden cardiac death whereas omega-3 fatty acids (found in fish oil) provide protection against cardiovascular diseases. At present, we are investigating effects of dietary fatty acids on endothelial cell function and vascular remodeling. We are also investigating the synergistic properties of omega-3 fatty acids with other nutrients, particularly polyphenols (found in fruits and vegetables), for their beneficial cardio-protective and anti-cancer properties. One other aspect of my research is to investigate processes that lead to muscle wasting (cachexia) in chronic diseases, particularly in cancer patients, and to use nutritional compounds to prevent muscle wasting and improve quality of life in cancer patients. Area of Research:
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Prof. Dame Louise N. Johnson
E- mail:Louise.Johnson@biop.ox.ac.uk |
Louise Johnson read Physics at University College London and completed her PhD in Molecular Biophysics at the Royal Institution London (1965) under the supervision of Sir Lawrence Bragg and David Phillips where she worked on the structure of lysozyme, the first enzyme structure to be solved by X-ray diffraction. She joined the Laboratory of Molecular Biophysics at the University of Oxford in 1967. Her recent research has been with protein kinases and the regulatory molecules of the cell cycle and has included a structure based drug design programme. She was appointed to the David Phillips Chair of Molecular Biophysics in Oxford in 1990 and was elected Fellow of the Royal Society also in 1990. In 2003 she was appointed Director of Life Sciences at the Diamond Light Source, the UK's new synchrotron source and shares this position 50% with her appointment at Oxford. In 2003 she was awarded the title of DBE in the New Years Honors list.
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Dr. Farooq Rahman Soomro
E-mail: dr_farooq_02@yahoo.com |
Dr. Soomro is currently working as Senior Medical Officer (BPS-18) Incharge Leprosy Control Centre near Atta Turk Tower Larkana and for HIV/AIDS, Sindh Blood Transfusion Authority, Leishmaniasis at EDO health office Larkana. He is also Honorary Medical Consultant, Marie Adelaide Leprosy Centre Karachi. He has published many research papers in the field of dermatology especially leishmaniasis and Leprosy.
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Professor Saadiya Aziz Karim E-mail: saadiya.aziz@gmail.com
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Prof. Saadiya Aziz Karim is the Dean, Faculty of Medicine, University of Karachi. She is also the Chairperson, Obstetrics and Gynaecology, at Karachi Medical & Dental College and Abbasi Shaheed Hospital and former Principal, Karachi Medical & Dental College. She has played a pivotal role in the development of Undergraduate and Postgraduate training programmes and Research at the Aga Khan University, University of Karachi and the College of Physicians & Surgeons, Pakistan. She has been awarded Honorary Fellowship of the College of Physicians & Surgeons, Pakistan in consideration of long standing national service to the medical profession. Author of 24 publications, including original research and chapters in international books, her current research focuses on relationship of nutritional parameters with pregnancy outcome and development of national screening programs for gynaecological cancer.
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Dr. Daniel Christian Hoessli
E-mail: Daniel.Hoessli@medecine.unige.ch |
Daniel Hoessli obtained his MD title at the University of Geneva, Switzerland. Following post-doctoral training in immunology at the Washington University (St.-Louis, MO) and Yale University (New Haven, CT), he pursued his research at the University of Geneva, focusing in the characterization of lymphocyte membrane receptors and was among the first to propose the concept of membrane microdomains, specialized lipid and protein environments that coordinate surface receptors with intracellular signaling molecules. Analyzing the signaling profile of tumoral lymphocytes (lymphoma cells) has led him to define the components of constitutively hyperactive signaling properties of lymphoma cells. The pathological “signalosomes” of lymphoma cells are anchored in membrane microdomains enriched in sphingolipids and could be targeted by both pharmacological and dietary therapeutic approaches. Area of Research:
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