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PCMD - M. PHIL., M. PHIL. LEADING TO PH.D., PH.D. ADMISSION PROGRAM – 2012 IN MOLECULAR MEDICINE
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Prospectus M.Phil., PhD, Program 2012

 

 

For admission details, Kindly visit the website of University of Karachi

http://www.uok.edu.pk/

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COURSE CONTENTS FOR ENTRANCE EXAM IN MOLECULAR MEDICINE

MOLECULAR BIOLOGY (30%)             

 

A. Gene Expression 

  1.  Replication
  2.  Transcription
  3.  RNA processing
  4. Translation

 B. Gene Regulation 

  1. Positive and negative control of the operon
  2. Promoter recognition by RNA polymerases
  3. Attenuation and anti termination

BIOCHEMISTRY (20%)

A. Biochemical Calculations

  1. Calculations: Preparation of reagents, buffers etc.
  2. Problems involving concentration expressions (molarity, percent and normality)

B. Structural Biology: Structure, Assembly, Organization, and Dynamics

  1. Small molecules (amino acids, monosaccharides, nucleotides and fatty acids)
  2. Macromolecules (nucleic acids, polysaccharides, proteins, and complex lipids)

C. Catalysis and Binding

  1. Basics of enzyme-substrate reaction, kinetics and mechanism.

D. Major Metabolic Pathways

  1. Synthesis and degradation of macromolecules (Proteins, Nucleic Acids, Carbohydrates)
  2. Regulation and Integration of Metabolism

GENETICS (15%)   

  1. Mendelian inheritance,
  2. Chromatin structure and Chromosomes, 
  3. Mitosis and Meiosis,
  4. Introns and Exons,
  5. Single copy and Repetitive DNA

PHYSIOLOGY (15%)         

A. Cell Physiology

  1. Cell Membrane.
  2. Cytoplasm
  3. Nucleus

B. Basics of Tissue Physiology

C. Basics of Nervous System Physiology

  1. Neurons
  2. Neuroglia
  3. Electrophysiology

D. Basics of Endocrine System

E. Basics of Cardiovascular, Respiratory, Digestive and Urinogenital Systems

PHARMACOLOGY (10%)

Basic Pharmacological aspects 

  1. Definition and branches of Pharmacology
  2. Dosage forms
  3. Routes of drug administration
  4. Pharmacokinetics
  5. Pharmacodynamics/ Drug-Receptor interaction

 

MICROBIOLOGY/IMMUNOLOGY (10%)        

Basic Microbiology 

> Procaryotic microorganisms and their classifications.
> Gram positive and Gram negative, and their diseases. 
> Mycobacteria, spirochetes, mycoplasma and Rickettsiae and their diseases.
> Chlamydia, protozoa, viruses and malaria parasites and their diseases.

Basic Immunology 

> Major components, characteristics and functions of the immune system.
> Types of immune mechanisms (Innate vs. adaptive, cellular vs. humoral)
> Immunological disorders (hypersensitivity, autoimmunity and immunodeficiency etc)